Publications

Yide Zhang, Peng Hu, Lei Li, Rui Cao, Anjul Khadria, Konstantin Maslov, Xin Tong, Yushun Zeng, Laiming Jiang, Qifa Zhou, Lihong V. Wang (2024). Ultrafast single-shot 3D photoacoustic tomography in vivo using a single-element detector. SPIE Photonics West 2024, San Francisco, California USA.

DOI Seno Medical Best Paper Award

Yide Zhang, Zhe He, Xin Tong, David C. Garrett, Rui Cao, Lihong V. Wang (2024). Quantum imaging of biological organisms using hyperentangled photon pairs. SPIE Photonics West 2024, San Francisco, California USA.

Xin Tong, Zhe He, Yide Zhang, Lei Li, Lihong V. Wang (2024). Super-resolution quantum microscopy at the Heisenberg limit. SPIE Photonics West 2024, San Francisco, California USA.

Xin Tong, Zhe He, Yide Zhang, Samuel A. Solomon, Li Lin, Qiyuan Song, Lihong V. Wang (2024). Experimental full-domain mapping of quantum correlation in Clauser-Horne-Shimony-Holt scenarios. SPIE Photonics West 2024, San Francisco, California USA.

Yide Zhang, Zhe He, Xin Tong, David C. Garrett, Rui Cao, Lihong V. Wang (2024). Quantum imaging of biological organisms through spatial and polarization entanglement. Science Advances, vol. 10, no. 10, pp. eadk1495.

DOI Featured News

Ruofan Cao, Yide Zhang, Jessica Houston (2024). Editorial: Phasor analysis for fluorescence lifetime data. Frontiers in Bioinformatics (Editorial), vol. 4, no. 1375480, pp. 1-2.

Yide Zhang, Peng Hu, Lei Li, Rui Cao, Anjul Khadria, Konstantin Maslov, Xin Tong, Yushun Zeng, Laiming Jiang, Qifa Zhou, Lihong V. Wang (2023). Ultrafast longitudinal imaging of haemodynamics via single-shot volumetric photoacoustic tomography with a single-element detector. Nature Biomedical Engineering.

Video DOI Nature Outlook: Medical Diagnostics Nature Biomedical Engineering’s News & Views Featured News NIH NIBIB’s Science Highlights

Yide Zhang (2023). Deep learning-enhanced microscopy with extended depth-of-field. Light: Science & Applications (News & Views), vol. 12, no. 284, pp. 1-3.

Zhe He, Yide Zhang, Xin Tong, Lei Li, Lihong V. Wang (2023). Quantum microscopy of cells at the Heisenberg limit. Nature Communications, vol. 14, no. 2441, pp. 1-8.

DOI Caltech’s 2023 Year in Review Featured News

Xin Tong, Zhe He, Yide Zhang, Samuel Solomon, Li Lin, Qiyuan Song, Lihong V. Wang (2023). Experimental full-domain mapping of quantum correlation in Clauser-Horne-Shimony-Holt scenarios. Physical Review Applied, vol. 19, no. 034049, pp. 1-16.

Yogeshwar Nath Mishra, Peng Wang, Florian J. Bauer, Yide Zhang, Dag Hanstorp, Stefan Will, Lihong V. Wang (2023). Single-pulse real-time billion-frames-per-second planar imaging of ultrafast nanoparticle-laser dynamics and temperature in flames. Light: Science & Applications, vol. 12, no. 47, pp. 1-12.

DOI Light: Science & Applications Top Downloads Featured News

Yide Zhang, Binglin Shen, Tong Wu, Jerry Zhao, Joseph C. Jing, Peng Wang, Kanomi Sasaki-Capela, William G. Dunphy, David Garrett, Konstantin Maslov, Weiwei Wang, Lihong V. Wang (2023). Ultrafast phase imaging of propagating current flows in myelinated axons and electromagnetic pulses in dielectrics. SPIE Photonics West 2023, San Francisco, California USA.

DOI Hitachi High-Tech Best Presentation Award

Xin Tong, Li Lin, Susana Cavallero, Yide Zhang, Shuai Na, Rui Cao, Tzung K. Hsiai, Lihong V. Wang (2023). Non-invasive photoacoustic computed tomography of cardiac anatomy and function in rats. SPIE Photonics West 2023, San Francisco, California USA.

Rui Cao, Jingjing Zhao, Lei Li, Lin Du, Yide Zhang, Yilin Luo, Laiming Jiang, Samuel P. Davis, Qifa Zhou, Adam de la Zerda, Lihong V. Wang (2023). Needle-shaped beam optical-resolution photoacoustic microscopy with an extended depth of field. SPIE Photonics West 2023, San Francisco, California USA.

Zhongtao Cheng, Chengmingyue Li, Anjul Khadria, Yide Zhang, Lihong V. Wang (2023). High-gain and high-speed wavefront shaping through scattering media. Nature Photonics, vol. 17, no. 2, pp. 1-9.

DOI Featured News

Li Lin, Xin Tong, Susana Cavallero, Yide Zhang, Shuai Na, Rui Cao, Tzung K Hsiai, Lihong V. Wang (2023). Non-invasive photoacoustic computed tomography of rat heart anatomy and function. Light: Science & Applications, vol. 12, no. 12, pp. 1-9.

Rui Cao, Jingjing Zhao, Lei Li, Lin Du, Yide Zhang, Yilin Luo, Laiming Jiang, Samuel Davis, Qifa Zhou, Adam de la Zerda, Lihong V. Wang (2022). Optical-resolution photoacoustic microscopy with a needle-shaped beam. Nature Photonics, vol. 17, no. 1, pp. 89-95.

DOI Nature Research Highlight Featured News

Rui Cao, Scott D. Nelson, Samuel Davis, Yu Liang, Yilin Luo, Yide Zhang, Brooke Crawford, Lihong V. Wang (2022). Label-free intraoperative histology of bone tissue via deep-learning-assisted ultraviolet photoacoustic microscopy. Nature Biomedical Engineering, vol. 6, no. 9, pp. 1-11.

DOI Featured News

Yide Zhang, Binglin Shen, Tong Wu, Jerry Zhao, Joseph C. Jing, Peng Wang, Kanomi Sasaki-Capela, William G. Dunphy, David Garrett, Konstantin Maslov, Weiwei Wang, Lihong V. Wang (2022). Ultrafast and hypersensitive phase imaging of propagating internodal current flows in myelinated axons and electromagnetic pulses in dielectrics. Nature Communications, vol. 13, no. 5247, pp. 1-12.

DOI Featured News

Varun Mannam, Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Vignesh Sundaresan, Siyuan Zhang, Cody Smith, Paul W. Bohn, Scott S. Howard (2022). Real-time image denoising of mixed Poisson–Gaussian noise in fluorescence microscopy images using ImageJ. Optica, vol. 9, no. 4, pp. 335-345.

Rui Cao, Scott D. Nelson, Samuel Davis, Yu Liang, Yilin Luo, Yide Zhang, Brooke Crawford, Lihong V. Wang (2022). Label-free ultraviolet photoacoustic histology via deep learning for rapid intraoperative diagnosis of bone cancer. SPIE Photonics West 2022, San Francisco, California USA.

Best Paper Award of Photons Plus Ultrasound Conference

Yide Zhang, Ian H. Guldner, Evan L. Nichols, David Benirschke, Cody J. Smith, Siyuan Zhang, Scott S. Howard (2021). Instant FLIM enables 4D in vivo lifetime imaging of intact and injured zebrafish and mouse brains. Optica, vol. 8, no. 6, pp. 885-897.

DOI Optica Top Downloads Control Software Analysis Software

Lei Li, Yang Li, Yide Zhang, Lihong V. Wang (2021). Snapshot photoacoustic topography through an ergodic relay of optical absorption in vivo. Nature Protocols, vol. 16, no. 5, pp. 2381-2394.

DOI Nature Protocols’ Featured Protocol of the Week

Varun Mannam, Yide Zhang, Xiaotong Yuan, Takashi Hato, Pierre C. Dagher, Evan L. Nichols, Cody J. Smith, Kenneth W. Dunn, Scott Howard (2021). Convolutional neural network denoising in fluorescence lifetime imaging microscopy (FLIM). SPIE Photonics West 2021, Online Only.

Code DOI BiOS’21 3-Minute Poster Prize

Varun Mannam, Yide Zhang, Xiaotong Yuan, Scott Howard (2021). Deep learning-based super-resolution fluorescence microscopy on small datasets. SPIE Photonics West 2021, Online Only.

Xiaotong Yuan, Varun Mannam, Yide Zhang, Scott Howard (2021). Overcoming the fundamental limitation of frequency-domain fluorescence lifetime imaging microscopy spatial resolution. SPIE Photonics West 2021, Online Only.

Varun Mannam, Yide Zhang, Xiaotong Yuan, Cara Ravasio, Scott S. Howard (2020). Machine learning for faster and smarter fluorescence lifetime imaging microscopy. Journal of Physics: Photonics, vol. 2, no. 4, pp. 042005.

Varun Mannam, Yide Zhang, Yinhao Zhu, Scott Howard (2020). Instant image denoising plugin for ImageJ using convolutional neural networks. Biomedical Optics 2020, Washington, DC USA.

Yide Zhang, Sergei Rouvimov, Xiaotong Yuan, Karla Gonzalez-Serrano, Alan C. Seabaugh, Scott S. Howard (2020). Resolution enhancement of transmission electron microscopy by super-resolution radial fluctuations. Applied Physics Letters, vol. 116, no. 4, pp. 044105.

Gang Bao, Yide Zhang, Zhigang Zeng (2020). Memory analysis for memristors and memristive recurrent neural networks. IEEE/CAA Journal of Automatica Sinica, vol. 7, no. 1, pp. 96-105.

Yide Zhang, Takashi Hato, Pierre C. Dagher, Evan L. Nichols, Cody J. Smith, Kenneth W. Dunn, Scott S. Howard (2019). Automatic segmentation of intravital fluorescence microscopy images by K-means clustering of FLIM phasors. Optics Letters, vol. 44, no. 16, pp. 3928-3931.

Code DOI Optics Letters’ Featured Paper of Volume 44, Issue 16

Yide Zhang, Yinhao Zhu, Evan Nichols, Qingfei Wang, Siyuan Zhang, Cody Smith, Scott Howard (2019). A Poisson-Gaussian denoising dataset with real fluorescence microscopy images. IEEE/CVF Conference on Computer Vision and Pattern Recognition (CVPR 2019), Long Beach, California USA.

Code Dataset DOI

Yide Zhang, Evan L. Nichols, Abigail M. Zellmer, Ian H. Guldner, Cody Kankel, Siyuan Zhang, Scott S. Howard, Cody J. Smith (2019). Generating intravital super-resolution movies with conventional microscopy reveals actin dynamics that construct pioneer axons. Development, vol. 146, no. 5, pp. dev171512.

Code Video DOI Featured News 1 Featured News 2

Yide Zhang, Ian H. Guldner, Evan L. Nichols, David Benirschke, Cody J. Smith, Siyuan Zhang, Scott S. Howard (2019). Three-dimensional deep tissue multiphoton frequency-domain fluorescence lifetime imaging microscopy via phase multiplexing and adaptive optics. SPIE Photonics West 2019, San Francisco, California USA.

DOI JenLab Young Investigator Award Video 1 Video 2 Featured News

Yide Zhang, David Benirschke, Ola Abdalsalam, Scott S. Howard (2019). Super-resolution multiphoton frequency-domain fluorescence lifetime imaging microscopy by generalized stepwise optical saturation (GSOS). SPIE Photonics West 2019, San Francisco, California USA.

Ola Abdalsalam, Yide Zhang, Scott Howard, Thomas D. O'Sullivan (2019). Self-calibrated frequency domain diffuse optical spectroscopy with a phased source array. SPIE Photonics West 2019, San Francisco, California USA.

Yide Zhang, David Benirschke, Ola Abdalsalam, Scott S. Howard (2018). Generalized stepwise optical saturation enables super-resolution fluorescence lifetime imaging microscopy. Biomedical Optics Express, vol. 9, no. 9, pp. 4077-4093.

Yide Zhang, Prakash D. Nallathamby, Evan L. Nichols, Cody J. Smith, Ryan K. Roeder, Scott S. Howard (2018). Super-resolution and high-speed quantitative multiphoton microscopy. Seventh Annual Harper Cancer Research Institute Research Day, Notre Dame, Indiana USA.

DOI Poster Contest Third Prize

Yide Zhang, Prakash D. Nallathamby, Genevieve D. Vigil, Aamir A. Khan, Devon E. Mason, Joel D. Boerckel, Ryan K. Roeder, Scott S. Howard (2018). Super-resolution fluorescence microscopy by stepwise optical saturation. Biomedical Optics Express, vol. 9, no. 4, pp. 1613-1629.

Code DOI NDIIF Award for Best Biological Imaging Publication 2018 Featured News

Yide Zhang, David Benirschke, Scott S. Howard (2018). Stepwise optical saturation microscopy: obtaining super-resolution images with conventional fluorescence microscopes. Biomedical Optics 2018, Hollywood, Florida USA.

Yide Zhang, David Benirschke, Scott S. Howard (2017). Super-resolution fluorescence imaging by stepwise optical saturation microscopy. IEEE Annual Mini-symposium on Electron Devices and Photonics, Notre Dame, Indiana USA.

Genevieve Vigil, Yide Zhang, Aamir Khan, Scott Howard (2017). Description of deep saturated excitation multiphoton microscopy for super-resolution imaging. Journal of the Optical Society of America A, vol. 34, no. 7, pp. 1217-1223.

Yide Zhang, Genevieve D. Vigil, Aamir A. Khan, Scott S. Howard (2017). Doubling the sensitivity of multiphoton frequency-domain fluorescence lifetime images. CLEO: Applications and Technology 2017, San Jose, California USA.

Genevieve D. Vigil, Yide Zhang, Aamir A. Khan, Scott S. Howard (2017). Simulation and experimental design of saturated excitation (SAX) multiphoton microscopy (MPM). CLEO: Applications and Technology 2017, San Jose, California USA.

Yide Zhang, Genevieve D. Vigil, Aamir A. Khan, Scott S. Howard (2017). Super-sensitivity and super-resolution multiphoton fluorescence lifetime imaging microscopy. NDnano Symposium: Nanotechnology in the Treatment of Neurodegenerative Disorders, Notre Dame, Indiana USA.

Aamir A. Khan, Genevieve D. Vigil, Yide Zhang, Susan K. Fullerton-Shirey, Scott S. Howard (2017). Silica-coated ruthenium-complex nanoprobes for two-photon oxygen microscopy in biological media. Optical Materials Express, vol. 7, no. 3, pp. 1066-1076.

Yide Zhang, Genevieve D. Vigil, Lina Cao, Aamir A. Khan, David Benirschke, Tahsin Ahmed, Patrick Fay, Scott S. Howard (2017). Saturation-compensated measurements for fluorescence lifetime imaging microscopy. Optics Letters, vol. 42, no. 1, pp. 155-158.

Yide Zhang, Aamir A. Khan, Genevieve D. Vigil, Scott S. Howard (2016). Super-sensitivity multiphoton frequency-domain fluorescence lifetime imaging microscopy. Optics Express, vol. 24, no. 18, pp. 20862-20867.

Yide Zhang, Aamir A. Khan, Genevieve D. Vigil, Scott S. Howard (2016). Investigation of signal-to-noise ratio in frequency-domain multiphoton fluorescence lifetime imaging microscopy. Journal of the Optical Society of America A, vol. 33, no. 7, pp. B1-B11.

Aamir A. Khan, Susan K. Fullerton-Shirey, Genevieve D. Vigil, Yide Zhang, Scott S. Howard (2016). Highly stable two-photon oxygen imaging probe based on a ruthenium-complex encapsulated in a silica-coated nanomicelle. CLEO: Applications and Technology 2016, San Jose, California USA.

Aamir A. Khan, Genevieve D. Vigil, Yide Zhang, Scott S. Howard (2016). Theoretical analysis of the signal-to-noise ratio of two-photon oxygen imaging probes. Biomedical Optics 2016, Fort Lauderdale, Florida USA.

Yide Zhang, Genevieve D. Vigil, Aamir A. Khan, Scott S. Howard (2016). High-resolution frequency-domain multiphoton fluorescence lifetime imaging microscopy. Fifth Annual Harper Cancer Research Institute Research Day, Notre Dame, Indiana USA.

Yide Zhang, Scott S. Howard (2015). On increasing the imaging rate of frequency-domain multiphoton fluorescence lifetime imaging microscopy. IEEE Annual Mini-symposium on Electronic and Photonics, Notre Dame, Indiana USA.

Shiping Wen, Zhigang Zeng, Tingwen Huang, Yide Zhang (2014). Exponential adaptive lag synchronization of memristive neural networks via fuzzy method and applications in pseudo random number generators. IEEE Transactions on Fuzzy Systems, vol. 22, no. 6, pp. 1704-1713.

Yide Zhang, Zhigang Zeng, Shiping Wen (2014). Implementation of memristive neural networks with spike-rate-dependent plasticity synapse. IEEE International Joint Conference on Neural Networks (IJCNN), Beijing, China.